Epigenetics role in ageing

Ageing is the primary risk factor for most diseases while the world population is becoming older. We study how epigenetics play a role in ageing and age-related diseases. By monitoring the changes of the epigenome at the single-cell level throughout ageing and in age-related diseases, we try to understand the epigenetic clock. We aim to achieve this by implementing novel multi-omics sequencing methods and modelling strategies. With a better view of the epigenetic clock, we hope to pinpoint the pathways where we can stall, stop or even reverse the process of ageing. On the other hand, we seek to directly rejuvenate aged organs, tissues or cells by partially resetting the epigenetic clock. We plan to characterize and perform fine-tuning on the process of reprogramming ex vivo and translate it into in vivo or a clinical setting.