New publication on single-cell DNA methylation age prediction, highlighting ageing heterogeneity in mouse blood
In the most recent publication by the von Meyenn Lab and collaborators, we generated a large single-cell DNA methylation and transcriptome dataset and developed scEpiAge, a single-cell DNA methylation age predictor.
We first generated a large single-cell DNA methylation and transcriptome dataset from mouse peripheral blood samples, spanning a broad range of ages. We next developed scEpiAge, a single-cell DNA methylation age predictor, which can accurately predict age in publicly available datasets, and also in single cells. Our work provides a foundation for single-cell and sparse data epigenetic age predictors, validates their functionality and highlights epigenetic heterogeneity during ageing.
Check out the publication here: external page https://www.nature.com/articles/s41467-024-51833-5